The site has associational significance with First Fleet Surgeon John White's family, Thomas Moore, the Anglican Church and Alderman Francis Mitchell. 145-151 George Street has associations with a number of retailers that occupied the sites over a considerable amount of time:·WA Grubb & Co, butchers at No.147 (1907-1910) and No.149-151 (1912-mid 1980s);·Nicholas, A & Co, fishmonger at No.151 (1898-1911) and No.147 (1911-at least to 1933);·Downton & Dyer Ltd, grocers at No.145 (Dyer, J from 1895-1917, Downton & Dyer 1918-mid 1980s) and No.147 (1879-1891).Of the above companies, WA Grubb & Co is well known as a butcher, operating branches throughout Australia, and who started his company from the George Street address.